Learn about side effects, warnings, dosage, and more. In summary, no one disputes our initial finding that clopidogrel is metabolized by CYP3A4, recognized by platelet aggregometry because of a presumed clopidogrel–atorvastatin interaction, but many other reports have not been able to confirm this interaction for various reasons. The intake of proton pump inhibitors within 12 hours of taking clopidogrel greatly reduces platelet … It works by irreversibly inhibiting a receptor called P2Y 12 on platelets. The most common clopidogrel interactions are seen in patients who use any type of proton pump inhibitor medications together with clopidogrel. Clopidogrel bisulfate reduces the likelihood of blood platelets clumping together and forming clots in blood vessels, resulting in a lower risk of stroke and heart attack. Drug information provided by: IBM Micromedex. Free E-newsletter Subscribe to Housecall. Fludarabine: (Moderate) Due to the thrombocytopenic effects of purine analogs, an additive risk of bleeding may be seen in patients receiving concomitant platelet inhibitors. Because of these differences, the metabolizer status does not always predict the same response for all drugs, even when those drugs are metabolized by that same gene. Learn about side effects, warnings, dosage, and more. Clopidogrel is metabolized by human cytochrome P450 3A and inhibited by atorvastatin. Clopidogrel is very efficient in reducing ischemic cardiovascular events but exposes patients to an increased risk of bleeding. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services.
Sign up now. What happens if a patient taking clopidogrel also takes a CYP2C19 inhibitor? Clopidogrel is an antiplatelet drug, which means that it prevents blood cells called platelets from sticking together (aggregating) and forming blood clots. Circulation. It is taken by mouth. Different drugs can be processed in different ways by the body. Clopidogrel is a prodrug, meaning it is initially inactive and must be metabolized to the active form in the body. Clopidogrel was patented in 1982, and approved for medical use in 1997. Clopidogrel, sold under the trade name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. Plavix (clopidogrel) is a brand-name prescription drug that’s used to help prevent cardiovascular events. Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).. Clopidogrel is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent). Clopidogrel (Oral Route) Print. Side Effects . Crossref Medline Google Scholar; 2 Lau WC, Waskell LA, Watkins PB, et al. Sections. The CYP2C19 enzyme plays a role in the processing or metabolizing of at least 10 percent of commonly prescribed drugs, including a drug called clopidogrel (also known as Plavix). Onset of effects is about two hours and lasts for five days. The clopidogrel–omeprazole interaction. In addition to clopidogrel, your genetic results for CYP2C19 can affect your response to other drugs. How is clopidogrel metabolized? When clopidogrel was given simultaneously with cangrelor and cangrelor was continued for 2 h, there was no inhibition of the P2Y 12 receptor by clopidogrel after the infusion was stopped because the clopidogrel active metabolite was unavailable for binding due to its short half-life . Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug interaction. Give some examples of strong, moderate, and weak CYP2C19 inhibitors.
About the Gene The gene of interest is called cytochrome P450-2C19 (CYP2C19; pronounced sip two see nineteen). Explain why a patient taking clopidogrel should avoid CYP2C19 inhibitors. The metabolization or activation of clopidogrel occurs in the liver by the action of cytochrome P450 … What enzymes are necessary? Plavix (clopidogrel) is a brand-name prescription drug that’s used to help prevent cardiovascular events. Clopidogrel is primarily metabolized to its active metabolite by CYP2C19; fluconazole is a potent CYP2C19 inhibitor. 2003; 107: 32–37. Drug Metab Dispos. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). Clopidogrel is in the thienopyridine-class of antiplatelets. Gilard et al.
2003; 31: 53–59. In patients with stable angina, clopidogrel administration alone is advisable whereas there is contraindication to or aspirin intolerance. Clopidogrel is a prodrug that has to be metabolized in the liver to generate the active metabolite, which selectively and irreversibly inhibits ADP – induced platelet aggregation targeting the ADP P2Y12 receptor on platelets. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.